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Therapeutic Antibodies
Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering.Current developments and clinical successes are summarised by experts in the drug development field.A must read for immunologists, clinical scientists and novel drug developers.
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Antibodies in Diagnosis and Therapy
Monoclonal antibodies have had their impact on biomedical research for more than a decade.Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle.With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway.The book reviews the status of technological development and brings this into the perspective of clinical results.A rapidly growing amount of clinical data is collected in an expanding number of indications.Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation.This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.
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Detection of HIV antibodies in oral mucosal transudate
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Overcoming Cancers Resistant to HER-2 Antibodies : Volume 2
Overcoming Cancers Resistant to HER-2 Antibodies provides general updated information on the resistance of various human cancers to anti-HER2 therapeutic antibodies.The book also discusses the description of various sensitizing agents that can reverse resistance when used in combination with anti-HER2 antibodies.There have been a lot of reports in which the treatment with anti-HER2 antibodies for various cancers has resulted in clinical responses; however, there have been also subsets of cancer patients who did not respond initially, and several responding patients developed resistance following treatments.Sections cover Lapatinib, Ganetespib, Paclitaxel, Celecoxib, Emantasine, Liposomal Doxorubicin, and Kinase Inhibitors. This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of the biomedical field interested in fighting cancer resistance to HER-2 antibodies.
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Why are Rhesus antibodies (D antibodies) injected after birth?
Rhesus antibodies, also known as D antibodies, are injected after birth to prevent a condition called hemolytic disease of the newborn (HDN). This condition occurs when a mother with Rh-negative blood type is exposed to Rh-positive blood from her baby during pregnancy or childbirth. The mother's immune system can develop antibodies against the Rh-positive blood, which can then attack the baby's red blood cells in future pregnancies. By injecting Rhesus antibodies after birth, any Rh-positive blood from the baby that may have entered the mother's bloodstream is targeted and destroyed before her immune system can develop its own antibodies, thus preventing HDN in future pregnancies.
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Why are Rhesus antibodies (D-antibodies) injected after birth?
Rhesus antibodies, also known as D-antibodies, are injected after birth to prevent a condition known as hemolytic disease of the newborn (HDN). This condition occurs when a mother with Rh-negative blood type is exposed to Rh-positive blood from her baby during pregnancy or childbirth, leading to the mother's immune system producing antibodies against the baby's red blood cells. By injecting Rhesus antibodies after birth, any Rh-positive red blood cells from the baby that may have entered the mother's bloodstream are destroyed before her immune system can mount a significant response, preventing HDN from occurring in subsequent pregnancies.
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What antibodies are there and which antibodies are present in which blood groups?
There are several types of antibodies, but the most commonly known are IgG, IgA, IgM, IgD, and IgE. In the context of blood groups, the most relevant antibodies are the ABO antibodies and the Rh antibodies. ABO antibodies are present in individuals who do not have the A or B antigens on their red blood cells, and they can have anti-A or anti-B antibodies depending on their blood type. Rh antibodies are present in individuals who are Rh-negative and can develop anti-Rh antibodies if exposed to Rh-positive blood.
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What does IgM antibodies mean?
IgM antibodies are a type of antibody produced by the immune system in response to an initial infection. They are the first antibodies to be produced in response to a new infection and are typically short-lived. IgM antibodies are important for the body's initial defense against pathogens, but they are eventually replaced by IgG antibodies, which provide long-term immunity.
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Everybody's Antibodies : Understanding Your Immune System in the World of Covid
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Freedom, Equality and Justice in Islam
In 'Freedom, Equality and Justice in Islam', M H Kamali presents the reader with an analysis of the three concepts of freedom, equality and justice from an Islamic point of view and their manifestations in the religious, social, legal and political fields.The author discusses the evidence to be found for these concepts in the Qur'an and 'Sunna', and reviews the interpretations of the earlier schools of law.The work also looks at more recent contributions by Muslim jurists who have advanced fresh interpretations of freedom, equality and justice in the light of the changing realities of contemporary Muslim societies. 'Freedom, Equality and Justice in Islam' is part of a series dedicated to the fundamental rights and liberties in Islam and should be read in conjunction with 'The Dignity of Man: An Islamic Perspective and Freedom of Expression in Islam.'
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Caring Democracy : Markets, Equality, and Justice
A rethinking of American democracy that puts caring responsibilities at the centerAmericans now face a caring deficit: there are simply too many demands on people’s time for us to care adequately for our children, elderly people, and ourselves.At the same time, political involvement in the United States is at an all-time low, and although political life should help us to care better, people see caring as unsupported by public life and deem the concerns of politics as remote from their lives.Caring Democracy argues that we need to rethink American democracy, as well as our fundamental values and commitments, from a caring perspective.What it means to be a citizen is to be someone who takes up the challenge: how should we best allocate care responsibilities in society?Joan Tronto argues that we need to look again at how gender, race, class, and market forces misallocate caring responsibilities and think about freedom and equality from the standpoint of making caring more just.The idea that production and economic life are the most important political and human concerns ignores the reality that caring, for ourselves and others, should be the highest value that shapes how we view the economy, politics, and institutions such as schools and the family.Care is at the center of our human lives, but Tronto argues it is currently too far removed from the concerns of politics.Caring Democracy traces the reasons for this disconnection and argues for the need to make care, not economics, the central concern of democratic political life.
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Play and Social Justice : Equity, Advocacy, and Opportunity
The importance of play for healthy development is undeniable.Aspects of play have been linked to the development of social skills, health and fitness, motivation, curiosity, innovation, imagination, and problem solving.Both theory and research suggest that play of various types is critical for healthy development and that playfulness is an important quality across the life span.However, opportunities to play and quality of play facilities in schools, after-school programs, childcare centers, community parks, and museums are not equitable by race, socio-economic status, and ability. And racial profiling, immigrant status, illness, and incarceration interfere with child’s play.The first section of the book defines play and social justice and describes disparities in play opportunities in childcare, schools, and communities as well as inequities in how play is interpreted.The next section describes pre-school, elementary, high school, and university programs that use play to liberate, teach, and build community as well as after-school, hospital, and community programs that help to level the playing field of opportunity.The final part of the book discusses ways to ameliorate inequities through research and advocacy.Four research methods are described that are useful for conducting studies on the amount of play children experience, attitudes toward play, and the effect of play on other variables.Finally, a child, a parent, and a teacher describe ways they tried to obtain more recess, using various methods of advocacy.The appendix provides resources indispensable for those convinced that play for all is indeed a social justice issue worthy of advocacy.
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How are humanized antibodies produced?
Humanized antibodies are produced by taking the variable region genes from a mouse antibody and combining them with the constant region genes from a human antibody. This process creates a chimeric antibody that retains the antigen-binding specificity of the mouse antibody while minimizing the potential for an immune response in humans. The resulting humanized antibody can then be produced using recombinant DNA technology in mammalian cell culture systems. This allows for the large-scale production of humanized antibodies for therapeutic use in treating various diseases, including cancer and autoimmune disorders.
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How many antibodies do you have?
As an AI language model, I do not have a physical body, so I do not have antibodies. Antibodies are produced by the immune system of living organisms to help fight off infections and diseases. Each person's immune system produces a unique set of antibodies to target specific pathogens. The number of antibodies a person has can vary depending on their individual immune response and exposure to different pathogens.
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Are immunoglobulins and antibodies the same thing?
Yes, immunoglobulins and antibodies are essentially the same thing. Immunoglobulins are a type of protein produced by the immune system in response to the presence of a foreign substance, such as a virus or bacteria. Antibodies are a specific type of immunoglobulin that specifically recognize and bind to these foreign substances, marking them for destruction by other immune cells. Therefore, while the terms are often used interchangeably, antibodies are a specific subset of the larger category of immunoglobulins.
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What is the difference between antigens and antibodies?
Antigens are molecules that can trigger an immune response in the body, such as viruses, bacteria, and other foreign substances. They are recognized by the immune system as being foreign and can stimulate the production of antibodies. Antibodies, on the other hand, are proteins produced by the immune system in response to the presence of antigens. They specifically bind to antigens and help to neutralize or eliminate them from the body. In summary, antigens are the foreign substances that trigger the immune response, while antibodies are the proteins produced by the immune system to target and neutralize antigens.
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