Products related to Specificity:
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New Experimental Probes for Enzyme Specificity and Mechanism : Volume 685
New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.
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Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity
A concise and accessible textbook covering ligand-binding theory in chemistry, biology, and drug development In Ligand-binding Basics: Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity, accomplished chemist Jannette Carey introduces ligand binding in a thorough and practical way for those new to the topic, as well as anyone seeking a connection between theory and experiment.Using a minimum of mathematical formalism, this book offers analytical rigor while remaining accessible to non-specialist practitioners.It provides readers with the skills they need to analyze their own binding data or published results, helping them develop an intuitive grasp of ligand-binding phenomena integrated with structural and thermodynamic understanding.Topics covered include: Application of the principles of equilibrium, mass action, and mass balance to derive the basic equations that describe all binding processesRecommended approaches for plotting and graphical analysis of binding dataStrategies for designing, analyzing, interpreting, and troubleshooting experiments from the perspective of ligand-binding theoryReview of selected examples that illustrate integration of structural and thermodynamic analysis Perfect for students and educators in chemistry, biochemistry, molecular biology, and pharmaceutical science, Ligand-binding Basics will also appeal to practitioners who aim to study ligand binding in any molecular system.
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Autobiographical Memory Specificity and Psychopathology : A Special Issue of Cognition and Emotion
It has been repeatedly demonstrated that depression and reported history of trauma are associated with a difficulty in retrieving specific autobiographical memories, a phenomenon called overgeneral memory (Williams & Broadbent, 1986).Over the past twenty years there has been a stimulating progression in knowledge in this field, and it is clear that the topic has a considerable level of importance, both from a theoretical and clinical perspective.This Special Issue is intended to further advance this field which lies at the heart of the cognition-emotion interface.Papers published in this Issue address key issues relating to the underlying mechanisms and aetiology of overgeneral autobiographical memory, providing a state-of-the-art and pushing the field forward.
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Freedom, Equality and Justice in Islam
In 'Freedom, Equality and Justice in Islam', M H Kamali presents the reader with an analysis of the three concepts of freedom, equality and justice from an Islamic point of view and their manifestations in the religious, social, legal and political fields.The author discusses the evidence to be found for these concepts in the Qur'an and 'Sunna', and reviews the interpretations of the earlier schools of law.The work also looks at more recent contributions by Muslim jurists who have advanced fresh interpretations of freedom, equality and justice in the light of the changing realities of contemporary Muslim societies. 'Freedom, Equality and Justice in Islam' is part of a series dedicated to the fundamental rights and liberties in Islam and should be read in conjunction with 'The Dignity of Man: An Islamic Perspective and Freedom of Expression in Islam.'
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What are substrate specificity and activity specificity using the example of restriction enzymes?
Substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. In the case of restriction enzymes, they have substrate specificity for particular DNA sequences, known as recognition sites. For example, the restriction enzyme EcoRI recognizes and binds to the DNA sequence GAATTC. Activity specificity, on the other hand, refers to the specific chemical reaction that an enzyme catalyzes. In the case of restriction enzymes, their activity specificity is to cleave the DNA at specific recognition sites. For example, EcoRI cleaves the DNA at the GAATTC sequence. In summary, substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule, while activity specificity refers to the specific chemical reaction that the enzyme catalyzes. In the case of restriction enzymes, they have substrate specificity for specific DNA sequences and activity specificity to cleave the DNA at those sequences.
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What is the actual difference between catalytic specificity and substrate specificity in enzymes?
Catalytic specificity refers to the ability of an enzyme to catalyze a specific chemical reaction, while substrate specificity refers to the ability of an enzyme to bind to a specific substrate. In other words, catalytic specificity is about the type of reaction that an enzyme can catalyze, while substrate specificity is about the specific molecule that an enzyme can bind to and act upon. Enzymes can have different levels of specificity for both their catalytic activity and their substrate binding, which allows them to carry out specific functions in the cell.
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What is the substrate specificity of enzymes?
The substrate specificity of enzymes refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. Enzymes are highly specific in their interactions with substrates, as they have active sites that are uniquely shaped to accommodate specific substrates. This specificity ensures that enzymes only catalyze specific reactions and do not interact with other molecules in the cell. Substrate specificity is crucial for the efficiency and regulation of biochemical reactions in living organisms.
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What is the group specificity of enzymes?
Group specificity of enzymes refers to the ability of an enzyme to act on a specific functional group within a substrate molecule. This means that the enzyme can only catalyze a reaction involving a particular functional group, such as an alcohol or an amine. Enzymes with group specificity are highly selective and only interact with substrates that contain the specific functional group that they are designed to act upon. This specificity is important for the regulation and control of biochemical pathways in living organisms.
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Caring Democracy : Markets, Equality, and Justice
A rethinking of American democracy that puts caring responsibilities at the centerAmericans now face a caring deficit: there are simply too many demands on people’s time for us to care adequately for our children, elderly people, and ourselves.At the same time, political involvement in the United States is at an all-time low, and although political life should help us to care better, people see caring as unsupported by public life and deem the concerns of politics as remote from their lives.Caring Democracy argues that we need to rethink American democracy, as well as our fundamental values and commitments, from a caring perspective.What it means to be a citizen is to be someone who takes up the challenge: how should we best allocate care responsibilities in society?Joan Tronto argues that we need to look again at how gender, race, class, and market forces misallocate caring responsibilities and think about freedom and equality from the standpoint of making caring more just.The idea that production and economic life are the most important political and human concerns ignores the reality that caring, for ourselves and others, should be the highest value that shapes how we view the economy, politics, and institutions such as schools and the family.Care is at the center of our human lives, but Tronto argues it is currently too far removed from the concerns of politics.Caring Democracy traces the reasons for this disconnection and argues for the need to make care, not economics, the central concern of democratic political life.
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Play and Social Justice : Equity, Advocacy, and Opportunity
The importance of play for healthy development is undeniable.Aspects of play have been linked to the development of social skills, health and fitness, motivation, curiosity, innovation, imagination, and problem solving.Both theory and research suggest that play of various types is critical for healthy development and that playfulness is an important quality across the life span.However, opportunities to play and quality of play facilities in schools, after-school programs, childcare centers, community parks, and museums are not equitable by race, socio-economic status, and ability. And racial profiling, immigrant status, illness, and incarceration interfere with child’s play.The first section of the book defines play and social justice and describes disparities in play opportunities in childcare, schools, and communities as well as inequities in how play is interpreted.The next section describes pre-school, elementary, high school, and university programs that use play to liberate, teach, and build community as well as after-school, hospital, and community programs that help to level the playing field of opportunity.The final part of the book discusses ways to ameliorate inequities through research and advocacy.Four research methods are described that are useful for conducting studies on the amount of play children experience, attitudes toward play, and the effect of play on other variables.Finally, a child, a parent, and a teacher describe ways they tried to obtain more recess, using various methods of advocacy.The appendix provides resources indispensable for those convinced that play for all is indeed a social justice issue worthy of advocacy.
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Arctic Justice : Environment, Society and Governance
EPDF and EPUB available Open Access under CC-BY-NC-ND licence. Offering a unique introduction to the study of justice in the European, North American and Russian Arctic, this collection considers the responsibilities and failures of justice for environment and society in the region.Inspired by key thinkers in justice, this book highlights the real and practical consequences of postcolonial legacies, climate change and the regions’ incorporation into the international political economy.The chapters feature liberal, cosmopolitan, feminist, as well as critical justice perspectives from experts with decades of research experience in the Arctic.Moving from a critique of current failures, the collection champions a just and sustainable future for Arctic development and governance.
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G. A. Cohen : Liberty, Justice and Equality
G. A. Cohen was one of the towering political philosophers of the late twentieth and early twenty-first centuries.His intellectual career was unusually wide-ranging, and he was celebrated internationally not only for his penetrating ideas about liberty, justice and equality, but also for his method, a highly original and influential combination of analytical philosophy and Marxism. Christine Sypnowich guides readers through the rich body of Cohen’s work.By identifying five paradoxes in his thought, she explores the origins of his interest in analytical philosophy, his engagement with the ideas of right-wing libertarianism, his critique of John Rawls’s work, his late-career turn to conservatism, and the tension between his preoccupation with individual responsibility and the idea of a socialist ethos.Sypnowich acknowledges the strengths of Cohen’s positions as well as their tensions and flaws, and presents him as a thinker of startling insight. This compelling introduction is a go-to resource for students and scholars of modern political philosophy.
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What is the biosubstrate specificity of bonds?
The biosubstrate specificity of bonds refers to the ability of enzymes to selectively bind to specific substrates and catalyze specific chemical reactions. Enzymes have specific active sites that are complementary to the shape and chemical properties of their substrates, allowing them to form temporary bonds and facilitate the conversion of substrates into products. This specificity is crucial for the regulation of biochemical pathways and the overall functioning of biological systems. It ensures that the right reactions occur at the right time and in the right place within the cell.
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What is the specificity of enzymes on substrates?
Enzymes are highly specific in their interactions with substrates, meaning that each enzyme typically catalyzes a specific chemical reaction with a specific substrate. This specificity is due to the unique three-dimensional shape of the enzyme's active site, which is complementary to the shape and chemical properties of its specific substrate. The enzyme-substrate interaction is often compared to a lock and key, where the enzyme (lock) can only bind to its specific substrate (key) due to their precise matching shapes and chemical properties. This specificity ensures that enzymes can efficiently catalyze specific reactions without interfering with other cellular processes.
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What does the term cell type specificity mean?
Cell type specificity refers to the unique characteristics and functions of a particular type of cell within an organism. It means that certain cells are specialized to perform specific tasks or functions within the body, and they have distinct molecular and structural features that enable them to carry out these functions. This specificity allows for the coordination and regulation of various physiological processes within the organism, as different cell types can perform their specialized roles in a coordinated manner. Understanding cell type specificity is important for studying the development, function, and dysfunction of different tissues and organs in the body.
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Could you please provide an urgent response regarding specificity of action?
Specificity of action refers to the ability of a treatment or intervention to target a particular problem or condition without affecting other parts of the body. It is important to consider the specificity of action when choosing a treatment to ensure that it effectively addresses the intended issue without causing unnecessary side effects or harm to other areas. It is also important to consult with a healthcare professional to determine the most appropriate and specific treatment for a particular condition.
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